T helper 17/regulatory t cell balance and experimental models of peritoneal dialysis-induced damage

摘要

Fibrosis is a general complication in many diseases. It is the main complication during peritoneal dialysis (PD) treatment, a therapyfor renal failure disease. Local inflammation and mesothelial to mesenchymal transition (MMT) are well known key phenomenain peritoneal damage during PD. New data suggest that, in the peritoneal cavity, inflammatory changes may be regulated at least inpart by a delicate balance between T helper 17 and regulatory T cells. This paper briefly reviews the implication of the Th17/Tregaxisin fibrotic diseases. Moreover, it compares current evidences described in PD animal experimental models, indicating a lossof Th17/Treg balance (Th17 predominance) leading to peritoneal damage during PD. In addition, considering the new clinicaland animal experimental data, new therapeutic strategies to reduce the Th17 response and increase the regulatory T response areproposed.Thus, future goals should be to develop newclinical biomarkers to reverse this immunemisbalance and reduce peritonealfibrosis in PD.